#4637 IS THE NEUTROPHIL/LYMPHOCYTE RATIO USEFUL IN PREDICTING THE OCCURRENCE OF DEPRESSION IN CHRONIC HEMODIALYSIS PATIENTS?

Abstract Background and Aims Depression is one of the most described psychiatric disorders in chronic hemodialysis patients. Previous studies have shown that inflammatory state involved progression depressive symptoms. The neutrophil/lymphocyte ratio (NLR) an inexpensive easily measured marker. To date, association between NLR depression this population Morocco has never been described. Method In multicenter cross-sectional study, we included a patients over period 3 months (September- December 2023). Patient Health Questionnaire-9 (PHQ-9) translated into Arabic (validated version) was used to assess calculated as neutrophils lymphocytes. An N/L greater than 2.5 considered high. We also patients' medical records collect data on their biological tests history. Results A total 69 with M/F sex 1.2. mean duration HD 7 ± 3.5 years, age 53 13.2 years. 28% were diabetic 32% hypertensive. Depressive symptoms detected 20% patients, 72% our had >2.5. univariate analysis, PHQ-9 scores positively correlated negatively albumin. There no correlation score sex, age, dialysis, diabetes, hypertension, ferritin. significant predictor mild (p = 0.06) moderate or moderately severe 0.04) symptoms, after adjusting for gender, Kt/V, history diabetes Charlson Comorbidity Index score. Conclusion These results suggest can be biomarker predict